Survival horror is supposed to be stressful, but Resident Evil 0 is a different beast entirely. It’s the black sheep. Most people remember the train, the gorgeous pre-rendered backgrounds, and that absolute nightmare of a hookshot. If you’re looking for a Resident Evil 0 remake walkthrough that actually deals with the game's specific brand of inventory management torture, you’re in the right place. Honestly, this game doesn't care if you're having a good time. It wants you to struggle.
The HD Remaster (which most people call the remake) didn’t fix the core "problem" of the original: there are no item boxes. None. You drop your stuff on the floor and hope you remember where you left it. It’s a polarizing mechanic that turns the game into a logistics simulator with occasional zombies.
The Ecliptic Express Is Just the Warm-up
The game starts fast. You’re Rebecca Chambers, a rookie who’s way out of her depth, and Billy Coen, a convict who is surprisingly good at playing the piano. The train is a claustrophobic masterpiece. It teaches you the basics of "partner zapping," which is basically just switching between characters to solve puzzles.
Don't ignore the difference in stats. Billy is a tank. He can take more hits and push heavy objects. Rebecca is fragile but can mix herbs. If you're playing on Hard, Rebecca is basically a glass cannon without the cannon part.
Why the Hookshot is Your Worst Enemy
Seriously. If you take one piece of advice from this Resident Evil 0 remake walkthrough, let it be this: do not leave the hookshot behind once you finish the train. You’ll find it in the small room near the back of the express. You use it to get onto the roof. Once the train crashes and you transition to the Training Facility, the game lets you drop it.
Don't.
You will need it again much later in the Laboratory and the Factory. If you leave it at the crash site, you are going to spend twenty minutes backtracking through rooms filled with Eliminators (those fast, annoying monkeys) just to go get it. It takes up two slots. It’s heavy. It’s annoying. Carry it anyway. Or at least drop it in the main hall of the Training Facility so it’s central.
Managing the Training Facility Hub
The Training Facility is the meat of the game. It’s your classic Resident Evil mansion layout. You have a grand hall with a typewriter and plenty of floor space. Since there are no item boxes, this hall becomes your "junk drawer."
Pro tip: Separate your items by type. Put all your healing items in one corner and your key items in another. It sounds OCD, but when you’re being chased by a Leech Man and you’re bleeding out, you don't want to be squinting at the floor trying to find a Green Herb.
The Leech Man Problem
You’ll encounter these things early. They look like Dr. Marcus and then turn into a pile of sentient sludge. Shooting them with a handgun is a waste of time. They explode when they die, which will likely kill you if you're close.
- Fire is the only answer. Use Molotov cocktails.
- Billy can craft them if you find empty bottles and gasoline.
- Flame rounds in the grenade launcher work too.
- If you don't have fire, just run. Seriously. Most Leech Men can be dodged if you’re patient.
Navigating the Puzzles and Character Swapping
The puzzles in this game are... weird. The animal statue puzzle in the basement is a classic "read the lore" moment. You have to light the torches in order based on the food chain.
- Deer
- Wolf
- Horse
- Lion
- Snake
- Eagle
If you mess it up, the torches reset and you have to fight some bugs. It's not the end of the world, but it's annoying.
The real challenge of a Resident Evil 0 remake walkthrough isn't the puzzles, though. It's the "Rebecca is trapped" sequences. There are multiple points where the duo gets separated. Usually, Rebecca ends up in a vent or a small room, and Billy has to do the heavy lifting to get her out. Always ensure Rebecca has at least one full heal and a decent weapon (like the Shotgun) before you interact with anything that looks like a trapdoor or an elevator.
The Mid-Game Slump: Laboratory and Church
Once you leave the facility, you hit the Church. This is where the Bat boss lives. It’s a notoriously janky fight because the auto-aim hates the tiny bats that fly around the big one.
Strategy for the Bat: Stay in the corners. Use the shotgun for the small bats and the grenade launcher (Acid or Flame) for the big guy. If you stay in the middle of the room, you'll get picked up and dropped, which does massive damage.
After the church, you head into the Lab. This area is shorter but denser. You’ll find the Stripper (the chemical, not a person) which Rebecca needs to mix in her mixing kit. Red, Green, and Blue chemicals are scattered around. You need these to create the battery acid and other key items. This is the only part of the game where Rebecca’s unique ability is mandatory.
Final Stretch: The Treatment Plant
By the time you reach the Treatment Plant, you should have the Magnum. Save your Magnum rounds for the final boss, the Queen Leech. Do not use them on Hunters. Use the Shotgun on Hunters. Aim at their feet to trip them up, then blast them while they're down.
The final boss has two stages. The first is a straightforward "shoot it until it dies" affair. The second stage is a protect mission. Rebecca has to open four valves while Billy distracts the monster.
This is where people fail.
You need to be aggressive with Billy. Stand right in the Queen's face. Use the Shotgun or the Magnum to flinch her. If she targets Rebecca, the mission is basically over because Rebecca has no defense while turning the valves. It’s a test of everything you’ve learned about the partner system.
Actionable Steps for Your Playthrough
If you want to actually finish this game without screaming, follow these specific rules:
- The 2-Slot Rule: Never let both characters have full inventories. Always keep at least two slots open between them. You never know when you’ll find a key item that requires two slots (like the Battery or the Large Gear).
- The Shotgun Distribution: Give Billy the Shotgun and Rebecca the Grenade Launcher. Billy’s higher HP allows him to get close for maximum damage, while Rebecca can stay back and lob grenades.
- Ink Ribbon Conservation: On Normal mode, you get plenty, but on Hard, they are scarce. Only save after major milestones: finishing the train, solving the clock puzzle, and before the Bat boss.
- Check the Map: The map in the remake is actually helpful. It highlights items you've dropped. If you lose your Grenade Launcher, look for the little green dots on the map screen.
- Kill the Zombies: In the Training Facility main hall and the corridors leading to it, kill everything. You’ll be walking through these halls fifty times. It’s worth the ammo to make them safe zones.
The Resident Evil 0 Remake is a game of patience. It rewards players who think three steps ahead and punishes those who treat it like a standard action game. Treat the floor as your best friend, keep the hookshot closer than your partner, and always keep a bottle of gasoline ready for the leeches.
To progress efficiently, start by clearing the Ecliptic Express and focusing on Billy's strength for the initial boss fights. Once you reach the Training Facility, designate the main hall as your primary storage hub. Prioritize finding the Grenade Launcher in the 2F office area to handle the upcoming Leech Man encounters. Use Rebecca's mixing kit to store Green Chemicals early, as you'll need them for the stripping agent later in the game. Finally, ensure you leave the "Duralumin Case" for Billy to open, as it contains the Handgun Parts that significantly boost his fire rate for the endgame.
